"We hope this study will lead to a broader understanding and appreciation of the fact that excessive consumption of alcohol has a negative effect on vitamin A function in the body," said one of the researchers Robin Clugston from Columbia University Medical Center in New York, New York.
He added, "Ultimately, we hope that vitamin A will be seen as a broad target for alcohol in multiple tissues of the body and that our understanding of alcohol-induced disease will be linked together by its effects on vitamin A."
Clugston and colleagues conducted multiple experiments using several groups of mice including those who received alcohol-containing food and alcohol-free food. They analysed the liver and other organs (kidney, spleen, heart, lung, white adipose, brown adipose and blood), from both groups of mice and measured tissue vitamin A levels.
The alcohol-fed mice had distinct changes in how their body handled vitamin A. In general, vitamin A levels were lower in the liver and higher in other tissues. This strongly suggests that vitamin A in the liver is reduced by excessive alcohol consumption and that these findings are important in the development of alcoholic liver disease.