The findings showed that sulforaphane may work through its influence on long, non-coding RNAs (lncRNAs) while offering a new way to specifically prevent or slow the progression of malignant cells. One type of lncRNA called LINC01116 is upregulated in a human cell line of prostate cancer, but can be decreased by treatment with sulforaphane, the researchers said.
"The study showed that treatment with sulforaphane could normalise the levels of this lncRNA," said Laura Beaver, Research Associate at Oregon State University in the US.
The impact of diet on lncRNA expression has been largely unknown until now, the researchers noted, in the paper published in the Journal of Nutritional Biochemistry. In this study, when LINC01116 was disrupted, there was a four-fold decrease in the ability of prostate cancer cells to form colonies.
"This may relate to more than just cancer prevention. It would be of significant value if we could develop methods to greatly slow the progress of cancer, help keep it from becoming invasive," Beaver added.
The study "reinforces the idea that lncRNAs are an exciting new avenue for chemoprevention research, and chemicals derived from diet can alter their expression," the researchers said.
Inputs from IANS
Often touted as the exotic cousin of cauliflower, broccoli comes loaded with a host of health benefits. It is a green veggie that you should make most use of by tossing into salads, stir-fries, curries and like. According to Oregon State University in the US, increasing your intake of cruciferous vegetables such as broccoli may lower the risk of developing prostate cancer. Cruciferous vegetables are high in sulforaphanes, which are compounds that help in the production of enzymes that fight against cancer-causing substances in the body. Among men, prostate cancer is the second most frequently diagnosed cancer globally.