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The study included non-diabetic patients who had untreated stage 1 hypertension (systolic blood pressure between 140 and 159 mmHg and/or diastolic blood pressure between 90 and 99 mmHg). Coffee consumption was categorised by the number of caffeine-containing cups per day: non-drinkers (0), moderate (one-three) and heavy drinkers (four or more). As Type 2 diabetes often develops in hypertensive patients at a later stage, the study examined the long-term effect of coffee drinking on the risk of developing pre-diabetes. A linear relationship was found, with a 100 percent (30 percent-210 percent) increased risk of pre-diabetes in the heavy coffee drinkers.
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"Our study shows that coffee use is linearly associated with increased risk of cardiovascular events in young adults with mild hypertension. We found that drinking coffee increases the risk of pre-diabetes in young adults with hypertension who are slow caffeine metabolisers," ," said lead researcher Dr Lucio Mos, cardiologist at Hospital of San Daniele del Friuli in Udine, Italy.
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Slow caffeine metabolisers have longer exposure to the detrimental effects of caffeine on glucose metabolism. "The risk is even greater if they are overweight or obese, and if they are heavy coffee drinkers. Thus, the effect of coffee on pre-diabetes depends on the amount of daily coffee intake and genetic background," he said. The blood pressure patients should be aware that coffee consumption may increase their risk of developing more severe hypertension and diabetes in later life and should keep consumption to a minimum, the authors said.
With inputs from IANS