A research study conducted at the Cleveland Clinic Lerner Research Institute in Ohio, US suggests how certain diet changes can neutralize the effect of diets that leads to deposition of fats and hardening of arteries increasing the risk of heart disease and stroke.
The research team inhibited TMA production using DMB in mice fed a high choline or carnitine diet. Until now, research efforts to lower TMAO levels have focused on suppressing the enzymes in people that convert TMA into TMAO. However, this approach causes liver damage as well as an unhealthy build-up of TMA."These studies demonstrate the exciting possibility that we can prevent or retard the progression of diet-induced heart diseases starting in the gut. This opens the door in the future for new types of therapies for atherosclerosis, as well as other metabolic diseases” said one of the researchers Stanley Hazen from Cleveland Clinic Lerner Research Institute in Ohio, US."We were able to show that 'drugging the microbiome' is an effective way to block this type of diet-induced heart disease. The inhibitor prevents formation of a waste product produced by gut microbes, leading to lowering of TMAO levels and prevention of diet-dependent atherosclerosis" Hazen added.This discovery may represent a potential new therapeutic approach for the prevention of heart disease, the researchers said. The study was published in the journal Cell.
Live: Bassist Mohini Dey Takes The Stage With Her Band At NDTV World Summit
Who Is Rajiv Mehta? Lilavati Hospital Trustee To Speak At NDTV World Summit 2026
Alain Ebobisse, Africa50 CEO, To Attend NDTV World Summit 2026. All About Him
Kriti Sanon At NDTV World Summit: A Look At Her Career And Business Ventures
Ex-CIA Director To Decode 'War In Times Of AI' At NDTV World Summit
NDTV World Summit 2026 Begins: India At The Centre Of A World Between Orders
'We Like To Spread That Magic': Mohini Dey Ahead Of NDTV World Summit Performance
NDTV World Summit 2026 Set To Begin: A Global Conversation On A World Between Orders
General Petraeus Praises India's Rise Ahead Of NDTV World Summit 2026
World-Class Chefs, Food And Music: The Fun Side Of NDTV World Summit 2026
The research team inhibited TMA production using DMB in mice fed a high choline or carnitine diet. Until now, research efforts to lower TMAO levels have focused on suppressing the enzymes in people that convert TMA into TMAO. However, this approach causes liver damage as well as an unhealthy build-up of TMA."These studies demonstrate the exciting possibility that we can prevent or retard the progression of diet-induced heart diseases starting in the gut. This opens the door in the future for new types of therapies for atherosclerosis, as well as other metabolic diseases” said one of the researchers Stanley Hazen from Cleveland Clinic Lerner Research Institute in Ohio, US."We were able to show that 'drugging the microbiome' is an effective way to block this type of diet-induced heart disease. The inhibitor prevents formation of a waste product produced by gut microbes, leading to lowering of TMAO levels and prevention of diet-dependent atherosclerosis" Hazen added.This discovery may represent a potential new therapeutic approach for the prevention of heart disease, the researchers said. The study was published in the journal Cell.